Open dotScribe from the normal application location for your setup. If you use the Windows portable/USB version, open it from the complete extracted portable folder instead.
Open the complete extracted dotScribe portable folder and launch dotScribe from there. Do not move only the application file away from the rest of the portable files. See Use and troubleshoot the Windows portable or USB version for the full workflow.
The Online Library also includes an Open dotScribe control that can hand off to the installed desktop app. See Open dotScribe Desktop from the Online Library.
Restart the computer once and try again. If the app is blocked by workplace security or operating-system controls, do not bypass those controls. Use the relevant installation or troubleshooting article, or contact dotScribe Support with the exact error message.